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Role of FBP1 in human malignancies
| Malignancy | Alterations | Downstream target | Reference |
|---|---|---|---|
| Oligodendrogliomas | FBP1 mutation | NA | 16 |
| Non-small cell lung cancer | FBP1↑ | Stathmin 1 ↑ | 77 |
| Breast | FBP1↑ | NA | 69,97 |
| Clear cell renal cancer | FBP1↑ | c-Myc↑ | 76 |
| Liver | FBP1↑ | p21↓ p15↓, Cyclin D2 ↑ | 15,19 |
| Liver | FBP1↑ | Stathmin 1 ↑ | 15,17 |
| Colon | FIR truncation | c-Myc↑ | 12,18 |
| Bladder | FBP1↑ | NA | 76 |
| Prostate | FBP1↑ | NA | 76 |
Abbreviations: FBP1, far upstream binding protein 1; FIR, FBP-interacting repressor.
