Fig. 1.

Nrf2 KO mice are more sensitive to ischemic reperfusion injury. Nrf2 KO mice and wild type littermates were subjected to 30 min ischemia by LAD coronary artery occlusion followed by 24 h reperfusion before quantification of infarct size or infarct over area-at-risk (AAR) following trypan blue perfusion and TTC staining. The data represent average ± standard deviations from 4 animals in each group. When two groups of means are compared, a statistical difference (p < 0.05) was determined by Student's t test and is labeled with *. When multiple groups of means were compared, ANOVA was used to determine statistical differences (p < 0.05). The means labeled “a” are significantly different from the means labeled “b” or “c”, while the difference between means labeled with “b” and “c” is statistically significant.