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. 2016 Jul 26;111(2):363–372. doi: 10.1016/j.bpj.2016.06.016

Figure 3.

Figure 3

PF-QNM AFM topography and elasticity mapping of DOPC/DPPC (1:1) SLBs after addition of fluvastatin. (a) Representative topography image (nm) and (b) height histogram analysis of topography (a) of the same DOPC/DPPC (1:1) SLBs as shown in Fig. 2a after ∼1 h of incubation with ∼10 μM fluvastatin. The dashed lines in (a) represent the domain edges defined by edge detection. The solid lines in (b) are Gaussian fits to height distribution of the whole height image, indicating an average height difference between the ld (blue line) and so (red line) domains of 0.86 nm. (c) Corresponding stiffness map (log scale, MPa) and (d) Young’s modulus values histograms (log scale, MPa) of the regions outlined in the topography (a) and stiffness (c) maps, corresponding to ld (blue) and so (red) domains. The solid lines are Gaussian fits to the distributions peaking at 27−10+75 MPa (ld) and 38−24+72 MPa (so). To see this figure in color, go online.