Table 1.

Sequential [Sepsis-Related] Organ Failure Assessment Score^a

System	Score
	0	1	2	3	4
Respiration
PaO2/FIO2, mm Hg   (kPa)	≥400 (53.3)	<400 (53.3)	<300 (40)	<200 (26.7) with respiratory support	<100 (13.3) with respiratory support
Coagulation
Platelets, ×103/µL	≥150	<150	<100	<50	<20
Liver
Bilirubin, mg/dL   (µmol/L)	<1.2 (20)	1.2–1.9 (20–32)	2.0–5.9 (33–101)	6.0–11.9 (102–204)	>12.0 (204)
Cardiovascular	MAP ≥70 mm Hg	MAP <70 mm Hg	Dopamine <5 or dobutamine (any dose)b	Dopamine 5.1–15 or epinephrine ≤0.1 or norepinephrine ≤0.1b	Dopamine >15 or epinephrine >0.1 or norepinephrine >0.1b
Central nervous system
Glasgow Coma Scale   scorec	15	13–14	10–12	6–9	<6
Renal
Creatinine, mg/dL   (µmol/L)	<1.2 (110)	1.2–1.9 (110–170)	2.0–3.4 (171–299)	3.5–4.9 (300–440)	>5.0 (440)
Urine output, mL/d				<500	<200

Abbreviations: FIO₂, fraction of inspired oxygen; MAP, mean arterial pressure; PaO₂, partial pressure of oxygen.

^aAdapted from Vincent et al.²⁷

^bCatecholamine doses are given as µg/kg/min for at least 1 hour.

^cGlasgow Coma Scale scores range from 3–15; higher score indicates better neurological function.