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Schematic illustration of epigenetic mechanisms (e.g., DNA hypermethylation) contributing to persistent elevation of reactive oxygen species (ROS) and activation of carotid body (CB) chemo reflex by long-term intermittent hypoxia (IH) in adults and neonatal IH. Dnmts= DNA methyl transferases; AOE= anti-oxidant enzymes. CB= Carotid body.
