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. 2016 May 3;107(6):846–852. doi: 10.1111/cas.12929

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© 2016 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Interactions between CD169⁺ macrophages in the regional lymph node (RLN) and CD8⁺ T cells or CD57⁺ NK cells in endometrial carcinoma (EC). (a) Immunohistochemical analyses of CD8⁺ T cells and CD57⁺ NK cells in tumor tissues. Scale bar, 50 μm. (b) Correlation between the number of CD8⁺ T cells or CD57⁺ NK cells in tumor tissues and the number of CD169⁺ macrophages or the CD169⁺‐to‐CD68⁺ macrophage ratio in RLN. (c) Overall survival curves for patients showing CD8⁺ T cells or CD57⁺ NK cells in tumor tissues. (d) Double immunostaining of CD169 and CD57 in RLN. Arrowheads indicate direct contacts between CD169⁺ cells and CD57⁺ cells. Scale bar, 50 μm.