Table 1.
Mice used in this experiment
| Wild-type mice | TNF-tg | P-value | TNFR1−/− | TNF-tg × TNFR1−/− | P-value | TNFR2−/− | TNF-tg × TNFR2−/− | P-value | |
|---|---|---|---|---|---|---|---|---|---|
| Number | 3 | 4 | 5 | 3 | 3 | 4 | |||
| Body weight (g) | 23.7±1.38 | 23.3±2.51 | NS | 23.9±0.60 | 26.0±0.08 | NS | 27.7±1.04 | 26.6±0.98 | NS |
| Lung volume (mL) | 0.32±0.08 | 0.87±0.05 | * | 0.29±0.03 | 0.32±0.05 | NS | 0.31±0.06 | 0.59±0.03 | * |
| RV/LV + S | 0.18±0.00 | 0.27±0.02 | * | 0.18±0.01 | 0.18±0.00 | NS | 0.17±0.00 | 0.21±0.01 | NS |
Notes:
*
Significant differences between TNF-tg-positive mice and transgene-negative mice. Data presented as mean ± standard deviation.
Abbreviations: LV, left ventricular; NS, no significance; RV, right ventricular; S, septa; TNF-α, tumor necrosis factor-α; TNF-tg, TNF-α transgene; TNFR, TNF receptor.