Fig. 1.

Triad determinants of mammalian ALOX15 orthologs including predicted and measured reaction specificity. The triad determinants of ALOX15 orthologs were retrieved from the databases. Only those entries were considered for further evaluation, for which the triad determinants have completely been sequenced. ALOX15 orthologs, for which the reaction specificity has been determined experimentally, are indicated in italic letters. On black background, those ALOX15 orthologs are indicated for which the reaction specificity has been determined for the first time in this study to our knowledge.