Skip to main content
. 2016 Jul 7;113(30):8490–8495. doi: 10.1073/pnas.1608873113

Fig. 1.

Fig. 1.

PD-1–deficient FoxP3-GFPcre mice show lethal autoimmunity. (A) Survival curve of male GFPcreKI/Y PD-1 WT (n = 20), male GFPcreKI/Y PD-1 KO (n = 8), female GFPcreKI/WT PD-1 WT (n = 20), female GFPcreKI/WT PD-1 KO (n = 23), female GFPcreKI/KI PD-1 WT (n = 11), and female GFPcreKI/KI PD-1 KO (n = 6) mice. (B) H&E staining of tissues (magnification, 50× and 200×). (C) FACS analysis of pancreas of 3- to ∼10-wk-old FoxP3-GFPcreKI/Y PD-1 WT or PD-1 KO mice. (D) Appearance of SPL and LNs. (E) FACS analysis of splenocytes. Data are representative of 3 to ∼7 mice per group. Bars represent the means (±SEM). *P < 0.05, **P < 0.01, ***P < 0.001.