Table S2.
Histological examination of Rag-2 KO mice with adoptive transfer
| Organ | Donor cells | Score | Inflammatory cell infiltration in the exocrine pancreas | Insulitis |
| Large intestine | CD8+ | 0 to ∼1 | ||
| ex-FoxP3 | 2 to ∼3 | |||
| ex-FoxP3 + CD8+ | 3 | |||
| CD44+RFP− | 3 | |||
| CD44+RFP− + CD8+ | 4 | |||
| Pancreas | CD8+ | 0 to ∼1 | 0 | |
| ex-FoxP3 | 2 | 0 to ∼1 | ||
| ex-FoxP3 + CD8+ | 1 | 0 to ∼1 | ||
| CD44+RFP− | 3 | 1 | ||
| CD44+RFP− + CD8+ | 1 to ∼2 | 0 to ∼1 |
The table summarizes the score of inflammation of the large intestine and pancreas from Rag-2 KO mice 3 wk after transfer of the combination of CD44+RFP− + CD8+ or 4 wk after transfer of other indicated T cells from pancreatic LNs and the pancreas of male FoxP3-GFPcreKI/Y Rosa-RFP PD-1 KO mice. Score 0, normal colon mucosa or absent of lymphocytic cell infiltration; score 1, mild mucosal changes or mild infiltrates; score 2, mucosal abrasion or moderate infiltrates; score 3, mucosal erosion, ulceration, or marked infiltrates; score 4, mucosa atrophy and few mitosis in crypt, or almost complete destruction of organs.