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. 2016 Jul 11;113(30):8514–8519. doi: 10.1073/pnas.1607079113

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Fig. S1. — Slower and incomplete reprogramming in aging fibroblasts (related to Fig. 1). Example images represent Tuj1 (green) and Map2 (red) immunoreactivity and nuclear stain (DAPI, blue) of iN cells derived from embryonic (MEF; Left), postnatal (4D; Second Left), adult (3M; Second Right) and aged (25M; Right) TTF at 1 wk (1W; Top), 2 wk (2W; Middle), and 3 wk (3W; Bottom) after doxycycline-mediated transgene induction. Note that the iN cells generated from postnatal, adult, and aged fibroblasts show limited neurite arborization at early timepoints, whereas MEF-iN cells display elaborate neuronal morphology already at 1 and 2 wk after doxycycline treatment. (Scale bar, 50 μm.)