Fig. 3.

FAAH regulates recovery of paw tissue structure and function after a surgical incision. (A) Time course (days) of recovery in mice treated with the FAAH inhibitor URB597 (1, 3, and 10 mg/kg, oral). The following parameters were evaluated: wound closure and scar formation (A1), paw edema (A2), heat hyperalgesia (A3), and mechanical allodynia (A4). (B) Time course of recovery in wild-type and Faah^−/− mice: wound closure (B1), edema (B2), hyperalgesia (B3), and allodynia (B4). Data are expressed as mean ± SEM (n = 9). *P < 0.05; **P < 0.01; ***P < 0.001 (compared with vehicle or wild-type mice, two-way ANOVA).