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. 2016 Jul 13;113(30):E4397–E4406. doi: 10.1073/pnas.1605578113

Fig. 6.

Fig. 6.

FAAH controls human keratinocyte migration and human fibroblasts transdifferentiation into myofibroblasts. (A and B) Representative image illustrating the motogenic effects of the FAAH inhibitor URB597 (0.5 or 1 μM; 18 h) in primary cultures of human keratinocytes (A) and quantitative analysis of leading edges distance (B). Data are expressed as percent of vehicle-treated control cultures (mean ± SEM). (C) Effects of URB597 (48 h) on keratinocyte proliferation. (D–F) Effects of synthetic NAT(20:0) on keratinocyte migration (18 h) (D and E) and keratinocyte proliferation (48 h) (F). (G–J) Effects of URB597 (0.5 μM, 48 h) on the expression of α-smooth muscle actin (G and H) and procollagen type I (I and J) in human fibroblasts. Data are expressed as mean ± SEM (n = 3). (Scale bars, 20 µm.) *P < 0.05; **P < 0.01; ***P < 0.001 (compared with vehicle mice, two-tailed Student’s t test).