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. 2016 Aug 1;11(8):e0158735. doi: 10.1371/journal.pone.0158735

Fig 3. Repetitive inhalant ODE exposure-stimulated serum IL-6 levels are partially reduced in TLR2 and TLR4 KO mice.

Fig 3

WT, TLR2 KO, and TLR4 KO mice were i.n. treated with ODE daily or saline for 3 weeks whereupon animals were euthanized 5 hrs following final exposure. Levels of IL-6 were determined in serum. Bar graphs represent the mean with standard error bars shown (N = minimum of 6 mice/group from 3 independent studies). Statistical significance denoted by asterisks (*p<0.05 **p<0.01, ***p<0.001) as compared to respective saline treatment group. Line denotes statistical significance (#p<0.05, ##p<0.01) of WT vs. TLR2 and TLR4 KO mice.