Table 2. Antiviral activity of interferon-α/β against KFDV and VSV-GFP virion production.

Interferon (IFN) Species	Concentration (U/mL)	Virus Titre Reduction From Mock-Treatedc	Virus Titre Reduction From Mock-Treatedc
A549		KFDV	VSV-GFP
2a	2, 000.0	0.5	6.9
	500.0	0.7	7.5
	62.5	0.7	4.7
	7.8	0.4	3.5
WA	2, 000.0	0.7	7.9
	500.0	0.6	7.0
	62.5	1.1	6.2
	7.8	0.5	3.6
K	2, 000.0	0.6	ND
	7.8	0.2	ND
Mock-Treateda	0.0	0.0	0.0
BHK-21		KFDV	VSV-GFP
2a	2, 000.0	0.9	4.4
	500.0	0.5	1.2
	62.5	0.1	0.7
	7.8	0.1	1.5
WA	2, 000.0	0.0	1.8
	500.0	0.1	-0.4
	62.5	0.2	0.1
	7.8	0.0	0.3
Mock-Treatedb	0.0	0.0	0.0

^a Titre reduction of mock-treated samples were calculated from original titres in A549 cells of 8.2 and 9.5 log₁₀ TCID₅₀/mL for KFDV and VSV-GFP, respectively.

^b Titre reduction of mock-treated samples were calculated from original titres in BHK-21 cells of 7.2 and 9.1 log₁₀ TCID₅₀/mL for KFDV and VSV-GFP, respectively.

^c Titre reduction expressed in log₁₀ scale TCID₅₀/mL.