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. 2016 Aug 1;11(8):e0160208. doi: 10.1371/journal.pone.0160208

Table 2. Histopathological differences between the three groups.

TAV-AS CBAV-AS CBAV-AR p value between TAV-AS vs. CBAV-AS p value between CBAV-AS vs. CBAV-AR
Number 24 24 24
Inflammation
 Grade 0 4 3 17 NS <0.01
 Grade 1 16 18 7
 Grade 2 4 3 0
 Grade 3 0 0 0
Neovascularization
 Grade 0 4 1 12 NS <0.01
 Grade 1 13 19 11
 Grade 2 7 4 1
 Grade 3 0 0 0
Calcium deposit
 Grade 0 0 0 15 NS <0.01
 Grade 1 0 0 7
 Grade 2 3 4 2
 Grade 3 21 20 0
Cholesterol deposit
 Grade 0 5 8 18 NS <0.01
 Grade 1 12 8 4
 Grade 2 6 6 2
 Grade 3 1 2 0
Fibrosis
 Grade 0 0 0 0 <0.01 <0.01
 Grade 1 18 1 9
 Grade 2 6 9 12
 Grade 3 0 14 3

TAV; tricuspid aortic valve, CBAV; congenital bicuspid aortic valve, AS; aortic stenosis, AR; aortic regurgitation, NS; not significant.