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. 2016 Jul 26;9:4549–4559. doi: 10.2147/OTT.S95962

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© 2016 Namvar et al. This work is published and licensed by Dove Medical Press Limited

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Fluorescent micrograph of AO/PI double-stained HL-60 cells that were treated with HA/ZnO nanocomposite.

Notes: (A) Untreated cells showing normal cell structure. (B) Treated cells after 24 h showing membrane blebbing, nuclear margination, and chromatin condensation. (C) Early apoptotic cells showing blebbing and nuclear fragmentation after 48 h treatment. (D) Late apoptotic cells showing nuclear fragmentation and apoptotic body formation after 72 h treatment (magnification 400×).

Abbreviations: AO/PI, acridine orange/propidium iodide; HL-60, acute promyelocytic leukemia cells; HA/ZnO, hyaluronan/zinc oxide; VC, viable cells; BL, membrane blebbing; CC, chromatin condensation; MN, marginated nucleus; EA, early apoptotic cells; FN, fragmented nucleus; LA, late apoptotic cells; AB, apoptotic body.