Table S1.

The clinical effects on animals during the experiments

Parameter	Clinical observations
General appearance	No dehydration, decreased body weight, missing anatomy, abnormal posture, hypothermia, fractured appendage, swelling, tissue masses, prolapse, and paraphimosis were found during this study.
Skin and fur	There was no discoloration, urine stain, pallor, redness, cyanosis, icterus, wound, sore, abscess, ulcer, alopecia, ruffled fur observed during this study.
Eyes	There was no exophthalmos, microphthalmia, ptosis, reddened eye, lacrimation, discharge and opacity observed during the study.
Nose, mouth, and head	No head tilted, nasal discharge, malocclusion, and salivation observed in the experimental animals.
Respiration	There was no sneezing, dyspnea, tachypnea, and rales observed in the animals during the study.
Urine	There was no discoloration, blood in urine, polyuria and anuria observed during the study.
Feces	Discoloration, blood in the feces, softness/diarrhea.
Locomotor	No hyperactivity, coma, ataxia, circling, muscle tremors observed in the animals.