Table 2.
Determination of anti-inflammatory activity of different derivatives of flurbiprofen by egg albumin-induced paw edema in mice
| Experimental groups | Diameter of inflamed paw (mm)
|
||||
|---|---|---|---|---|---|
| At 0 hours | At 1 hour | At 2 hours | At 3 hours | At 4 hours | |
| Control | 3.64±0.07 | 3.70±0.13 | 3.92±0.05 | 4.21±0.14 | 3.86±0.05 |
| Standard | 3.49±0.14 | 2.98±0.10** | 2.67±0.10*** | 2.23±0.20*** | 1.54±0.11*** |
| 4a | 3.78±0.05 | 3.52±0.08ns | 2.53±0.08*** | 2.32±0.03*** | 1.74±0.14*** |
| 4b | 3.48±0.10 | 3.10±0.04* | 2.66±0.06*** | 2.04±0.15*** | 1.77±0.15*** |
| 4c | 3.74±0.06 | 3.21±0.07** | 2.84±0.05*** | 2.43±0.06*** | 1.94±0.04*** |
| 4d | 3.64±0.07 | 3.23±0.06* | 3.03±0.04*** | 2.84±0.04*** | 2.34±0.14*** |
Notes: Results are measured as mean ± SEM using two-way ANOVA Bonferroni post-test. P-value <0.001 was considered as significant when compared with control;
*
P=0.05,
**
P=0.01,
***
P=0.001.
Abbreviations: ANOVA, analysis of variance; SEM, standard error of the mean.