Table 3.

Topological parameters of PPI networks

PPI network	Number of nodes	Number of edges	R2	Correlation	Clustering coefficient	Network centralization	Network density	Network diameter
Overall DEGs	366	1,858	0.836	0.880	0.304	0.214	0.028	9
Upregulated	194	1,122	0.749	0.849	0.404	0.280	0.060	8
Downregulated	130	262	0.859	0.996	0.213	0.204	0.031	9

Abbreviations: DEGs, differentially expressed genes; PPI, protein–protein interaction.