Table 7.
GO and KEGG pathway enrichment analyses of the most significant module of gene–gene interaction network with MCODE score 70.541 (top five in each)
| Category | Class | Description | Gene count | Adjusted P-value/FDR q-value |
|---|---|---|---|---|
| GO | ||||
| BP | 7,049 | Cell cycle | 47 | 3.4537E-39 |
| BP | 22,403 | Cell cycle phase | 37 | 5.8834E-35 |
| BP | 278 | Mitotic cell cycle | 35 | 4.0954E-34 |
| BP | 51,301 | Cell division | 33 | 5.9482E-34 |
| BP | 279 | M phase | 34 | 5.9482E-34 |
| Pathway | ||||
| KEGG | hsa04110 | Cell cycle | 21 | 1.35E-34 |
| KEGG | hsa04114 | Oocyte meiosis | 11 | 5.32E-15 |
| KEGG | hsa03030 | DNA replication | 7 | 1.15E-11 |
| KEGG | hsa04914 | Progesterone-mediated oocyte maturation | 8 | 7.63E-11 |
| KEGG | hsa04115 | P53 signaling pathway | 6 | 6.33E-08 |
Abbreviations: FDR, false discovery rate; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; MCODE, molecular complex detection; BP, biological process.