Figure 1.

Certain monogenic neurological diseases, particularly intellectual disability syndromes, are associated with mutations in chromatin modifying proteins. Shown at the left, examples include enzymes that “read” or “write” DNA and histone methylation, ATP-dependent chromatin remodelers, chaperone machinery for the RI histone variant H3.3, and H3.3 itself. A brief description of the functions for each gene product is listed to the right of each gene. Further to the right, the associated neurological diseases are given.