Full corneal thickness in 13 CED-affected dogs as measured by USP-Pachette dramatically differed in comparison to 11 unaffected controls. At the central, superior, inferior, and temporal locations, CED-affected dogs had significantly greater corneal thickness in comparison to control unaffected dogs. The nasal perilimbal cornea was significantly thinner than the central, inferior, and temporal locations in CED-affected dogs. The corneas of CED-unaffected dogs were significantly thinner centrally in comparison to the superior, inferior, nasal, and temporal perilimbal locations; temporal perilimbal cornea was also significantly thinner than the inferior cornea. Box plots depict median (solid line), mean (dashed line), 25th, and 75th percentiles, while whiskers show 10th and 90th percentiles; black circles indicate outliers. The P value was determined by a one-way ANOVA on ranks, **P < 0.01 and ***P < 0.001 between CED-unaffected and affected dogs or different locations of CED-affected dogs, and a,b,†P < 0.003 between the different locations of CED-unaffected dogs.