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. 2016 Jun 1;15(15):2009–2018. doi: 10.1080/15384101.2016.1192729

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© 2016 Taylor & Francis

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Figure 1. — SOX2 is specific modified in mitosis. (A) SOX2 was obviously modified in mitosis. In nocodazole (Noc., 50 ng/mL for 12 hours) treated human ovarian PA-1 cells, SOX2 exerts a slow-migration band observed by western blotting. Histone H3 was blotted as loading control. (B) Mitotic specific modifications of SOX2 can similarly observed in F9, H520 and MCF7 cell lines. (C) The modified SOX2 decayed along with the exit of mitosis. Mitotic PA-1 cells (arrested by nocodazole for 12 hours) were released for 0, 20, 30, 45, 60, 75, 90, 105 minutes. Cell cycle regulation and mitotic modified proteins CDT1 and geminin were examined for cell phase control and unchanged cullin-1 was blotted as loading control.