Table 1. Chromosome bands most affected by spontaneous breakage in exposed and non-exposed individuals six years after oil exposure.
Exposed individuals | Non-Exposed individuals | |
---|---|---|
Individuals | 47 | 22 |
Total breakpoints identified by G-banding | 251 | 110 |
Chromosome lesions | 149 | 63 |
Structural chromosome alterations | 102 | 47 |
Statistical methods used | ||
Fragile site multinomial (FSM method) | 1q32(5), 5q31(5), 6p21.2 (4), 7q22(4), 8p23(4), 9q22(4), 14q24(6), 17p11.2(5), 17q21(11), Xq22 (4) | 3p21 (3), 10p13(3), 11q13(4), 14q24 (3), 17q21(4) |
Statistical method using relative length of chromosome bands | 1q22(1), 1q32(5), 2q13(2), 2q21(3), 2q23(2), 2q34(2), 2q35(2), 3q25(3), 3q27(3), 4p15.2(2), 5q31(5), 6p11.2(1), 6p21.2(4), 6q21(3), 7p15(3), 7q22(4), 7q32(3), 8p23(4), 8q21.2(2), 9p22(2), 9q13(3), 9q22(4), 9q32(2), 12p12(3), 12p13.1(2), 14q24(6), 16p13.1(2), 17p11.2(5), 17p12(2), 17q21(11), 18p11.2(3), 19p13.2(2), Xq13(3), Xq22(4), Xq24(2) | 1p13(2), 1q21(2), 2p14(1), 2q11.2(2), 2q32(2), 3p21(3), 3q13.2(1), 4p16(2), 4q31.3(1), 4q33(1), 5p12(1), 5q22(2), 6p21.2(2), 6q25(2), 7p15(2), 9q13(2), 10p13(3), 10q22(2), 11p11((2), 11p14(2), 11q13(4), 12p13.1(1), 14q24(3), 15q23(1),16q13(2), 17p11.2(2), 17q12(1), 17q21(4) |
Numbers in parentheses indicate the breaks located in chromosome band. Bold chromosome bands are present only in exposed individuals using two statistical methods.