Table 3.

Ir-catalyzed allylation of acyclic α-alkoxy ketone enolates: scope of ketones.^[a]

^[a]The molar ratio of 1/2/3/LHMDS/CuBr = 2/1/0.02/2/2. The absolute configurations were assigned by analogy. The yields were reported as the combined yields of two diastereoisomers. The diastereomeric ratios were determined by ¹H NMR analysis of crude reaction mixtures. The enantiomeric excesses were determined by chiral SFC analysis of major isomers.

^[b]4 mol% of 3 was used.

^[c]1 equiv of CuBr was used.

^[d]0.5 equiv of CuBr was used.

^[e]cinnamyl acetate was used instead of cinnamyl carbonate, and the reaction time was elongated to 36 h. The yield was reported as the isolated yield of the major diastereomer.