Table 3.
Comparison of urinary symptoms, quality of life, and psychosocial measures among OAB patients with and without widespread systemic symptoms (adjusted for age and sex)
| OAB Only | OAB with widespread systemic symptoms | OAB without widespread systemic symptoms | p-value, adjusted for age and sex |
|---|---|---|---|
| No. of OAB subjects | 16 | 35 | |
| % of OAB subjects | 31.4% | 68.6% | |
| Age (mean ± SD) | 54.8 ± 9.2 | 53.3 ± 13.1 | 0.79 (not adjusted) |
| Sex (% females) | 88% | 66% | 0.18 (not adjusted) |
| Age of diagnosis of OAB (mean ± SD) | 49.0 ± 13.8 | 47.0 ± 16.1 | 0.78 |
| % with OAB symptoms less than one year? | 33.3% | 18.2% | 0.25 |
| No. of symptoms checked on the PSPS-Q (up to 59) | 32.0 ± 4.5 | 10.8 ± 8.2 | <0.001* |
| Urinary symptoms: (mean ± SD) | |||
| ICIQ-UI (urinary incontinence, 0-21) | 15.1 ± 4.2 | 10.6 ± 4.5 | 0.003* |
| ICIQ-OAB (overactive bladder, 0-16) | 10.1 ± 2.8 | 8.9 ± 2.5 | 0.11 |
| OAB-q symptom bother subscale (6-36) | 22.5 ± 6.4 | 17.6 ± 6.1 | 0.010* |
| OAB-q quality of life subscale (13-78) | 38.5 ± 17.3 | 25.5 ± 6.4 | 0.006* |
| UDI-6 (urogenital distress inventory, 0-24) | 16.4 ± 5.7 | 10.9 ± 4.7 | 0.002* |
| IIQ-7 (incontinence impact questionnaire, 0-28) | 13.3 ± 8.7 | 6.8 ± 7.1 | 0.002* |
| USS (urgency severity scale, 0-3) | 2.3 ± 0.7 | 2.1 ± 0.7 | 0.34 |
| Numeric rating scale of urgency (0-10) | 6.5 ± 3.0 | 6.0 ± 2.4 | 0.43 |
| Numeric rating scale of frequency (0-10) | 7.4 ± 2.0 | 5.9 ± 2.7 | 0.057 |
| Psychosocial measures: (mean ± SD) | |||
| Depression (HADS-D) | 6.9 ± 3.5 | 4.5 ± 3.8 | 0.011* |
| Anxiety (HADS-A) | 9.3 ± 3.4 | 6.6 ± 4.8 | 0.034* |
| Psychological stress level (PSS) | 22.1 ± 7.3 | 15.0 ± 7.5 | 0.002* |
| Exposure to childhood sexual trauma (CTES) | 38% | 26% | 0.41 |
| Sleep (PROMIS-8b) | 57.1 ± 8.9 | 53.0 ± 10.8 | 0.17 |
| Fatigue (PROMIS-7a) | 60.5 ± 7.1 | 52.1 ± 9.5 | 0.011* |
Note: Widespread systemic symptoms were operationalized as having ≥25 symptoms in ≥9 symptom groups in women, or ≥20 symptoms in ≥8 symptom groups in men among the symptoms listed in the Appendix. The operational definition was different between men and women because men do not have gynecological symptoms.
*
p<0.05