Table 2.
Baseline Characteristics of Propensity Score–Matched Participants
| Total (N = 1,962) | Aspirin (n = 981) | No Aspirin (n = 981) | Std Diff, % | |
|---|---|---|---|---|
| Age, y | 52.2 ± 9.2 | 52.2 ± 9.2 | 52.2 ± 9.4 | −0.2 |
| Female sex | 769 (39) | 384 (39) | 385 (39) | 0.2 |
| Race | ||||
| White | 1,505 (77) | 757 (77) | 748 (76) | −2.2 |
| Black | 338 (17) | 165 (17) | 173 (18) | 2.2 |
| Other | 119 (6) | 59 (6) | 60 (6) | 0.4 |
| Country | ||||
| United States | 1,413 (72) | 712 (73) | 701 (71) | −2.5 |
| Canada | 186 (9) | 96 (10) | 90 (9) | −2.1 |
| Brazil | 363 (19) | 173 (18) | 190 (19) | 4.5 |
| High-dose vitamin treatment arm | 950 (48) | 480 (49) | 470 (48) | −2.0 |
| Low-dose vitamin treatment arm | 1,012 (52) | 501 (51) | 511 (52) | 2.0 |
| Diabetes | 820 (42) | 413 (42) | 407 (41) | −1.2 |
| Hypertension | 1,826 (93) | 912 (93) | 914 (93) | 0.8 |
| Smoking | ||||
| Current | 201 (10) | 103 (11) | 98 (10) | −1.7 |
| Former | 759 (39) | 375 (38) | 384 (39) | 1.9 |
| Never | 1,002 (51) | 503 (51) | 499 (51) | −0.8 |
| Living donor | 862 (44) | 424 (43) | 438 (45) | 2.9 |
| CNI-based regimen | 1,761 (90) | 876 (89) | 885 (90) | 3.0 |
| Sirolimus use | 175 (9) | 86 (9) | 89 (9) | 1.1 |
| Statin use | 1,043 (53) | 519 (53) | 524 (53) | 1.0 |
| Transplant vintage, y | 3.6 [1.6–6.8] | 3.5 [1.5–6.9] | 3.8 [1.7–6.6] | −1.6 |
| BMI, kg/m2 | 29.1 ± 6.3 | 29.1 ± 6.3 | 29.1 ± 6.2 | −1.0 |
| Systolic BP, mm Hg | 136.0 ± 19.5 | 136.2 ± 20.0 | 135.9 ± 19.1 | −1.4 |
| Diastolic BP, mm Hg | 78.7 ± 12.0 | 78.7 ± 11.9 | 78.7 ± 12.1 | 0.1 |
| eGFR, mL/min/1.73 m2 | 50.0 ± 18.0 | 50.3 ± 18.2 | 49.8 ± 17.8 | −3.0 |
| eGFR strata | ||||
| ≤90 mL/min/1.73 m2 | 69 (4) | 33 (3) | 36 (4) | 1.7 |
| 60–90 mL/min/1.73 m2 | 411 (21) | 219 (22) | 192 (20) | −6.8 |
| 45–60 mL/min/1.73 m2 | 632 (32) | 305 (31) | 327 (33) | 4.8 |
| 30–45 mL/min/1.73 m2 | 631 (32) | 315 (32) | 316 (32) | 0.2 |
| <30 mL/min/1.73 m2 | 219 (11) | 109 (11) | 110 (11) | 0.3 |
| ACR, mg/g | 22.1 [7.8–78.5] | 21.2 [7.9–69.4] | 23.5 [7.7–82.7] | 6.1 |
| ACR strata | ||||
| <10 mg/g | 607 (31) | 305 (31) | 302 (31) | −0.7 |
| 10–29 mg/g | 513 (26) | 268 (27) | 245 (25) | −5.3 |
| 30–299 mg/g | 632 (32) | 307 (31) | 325 (33) | 3.9 |
| ≥300 mg/g | 210 (11) | 101 (10) | 109 (11) | 2.6 |
| Cholesterol | ||||
| Total, mg/dL | 184.3 ± 41.8 | 183.9 ± 43.2 | 184.8 ± 40.3 | 2.1 |
| HDL, mg/dL | 46.7 ± 14.0 | 46.9 ± 14.1 | 46.6 ± 13.9 | −2.2 |
| LDL, mg/dL | 101.0 ± 33.1 | 100.8 ± 32.9 | 101.2 ± 33.3 | 1.2 |
| Triglycerides, mg/dL | 163 [109–234] | 160 [109–230] | 166 [110–235] | 2.1 |
Note: Values for categorical variables are given as number (percentage); values for continuous variables, as mean 6 standard deviation or median [interquartile range].
Abbreviations: ACR, albumin-creatinine ratio; BMI, body mass index; BP, blood pressure; CNI, calcineurin inhibitor; eGFR, estimated glomerular filtration rate; HDL, high density lipoprotein; LDL, low density lipoprotein; Std Diff, standardized difference.