Kaplan-Meier curves of using tumor volume of the high-risk subregion (i.e., cluster A) to predict: a) overall survival, b) out-of-field progression, for the entire cohort (n = 44), and c) overall survival, d) out-of-field progression, for patients with stage III disease (n = 32). The cutoff between high vs low-risk patients was determined based on the median of predicted risk.