Table 2.

Responder Analysis for Yale Global Tic Severity Scale (YGTSS)

Responder Category	Patient	YGTSS Domain	Baseline	24 Months	Change (%)
	Subject
Non-Responder‡	5	Motor severity	20	16	−20.00	‡
		Phonic severity	18	19	5.56	‡
		Total severity	38	35	−7.90	‡
		Impairment	40	30	−25.00	†
		Total	78	65	−16.67	‡
	Subject
Full Responder*	4	Motor severity	25	10	−60.00	★
		Phonic severity	20	0	−100.0	★
		Total severity	45	10	−77.78	★
		Impairment	50	30	−40.00	★
		Total	95	40	−57.90	★
	Subject
Full Responder*	3	Motor severity	24	13	−45.84	★
		Phonic severity	24	5	−79.17	★
		Total severity	48	18	−62.50	★
		Impairment	40	30	−25.00	†
		Total	88	48	−45.46	★
	Subject
Non-Responder‡	2	Motor severity	25	25	0.00	‡
		Phonic severity	25	25	0.00	‡
		Total severity	50	50	0.00	‡
		Impairment	50	40	−20.00	‡
		Total	100	90	−10.00	‡
				18 Month
	Subject
Non-Responder‡	1	Motor severity	25	21	−16.00	‡
		Phonic severity	25	21	−16.00	‡
		Total severity	50	42	−16.00	‡
		Impairment	50	40	−20.00	‡
		Total	100	82	−18.00	‡
Mean Responder Outcomes		Motor severity	23	13	−41.95	★
		Phonic severity	20.67	8	−57.87	★
		Total severity	43.67	21	−49.40	★
		Impairment	43.34	30	−30.00	†
		Total	87	51	−40.01	★

^★Full Responder:≥40% improvement in YGTSS total score

^†Partial Responder=40%–25% improvement in YGTSS total score

^‡Non-Responder: < 25%improvement in YGTSS total score