Table 3.
Responder Analysis for Modified Rush Tic Rating Scale (MRTRS)
| Category | Patient | MRTRS Domain | Baseline | 24 Months | Change (%) | |
|---|---|---|---|---|---|---|
| Full Responder* | Subject 5 | No. of body areas | 4 | 3 | −25.00 | † |
| Motor tics/min | 2 | 1 | −50.00 | ★ | ||
| Phonic tics/min | 4 | 2 | −50.00 | ★ | ||
| Motor tic severity | 4 | 2 | −50.00 | ★ | ||
| Phonic tic severity | 4 | 2 | −50.00 | ★ | ||
| Total | 18 | 10 | −44.45 | ★ | ||
|
| ||||||
| Full Responder* | Subject 4 | No. of body areas | 4 | 1 | −75.00 | ★ |
| Motor tics/min | 4 | 1 | −75.00 | ★ | ||
| Phonic tics/min | 1 | 0 | −100.0 | ★ | ||
| Motor tic severity | 4 | 1 | −75.00 | ★ | ||
| Phonic tic severity | 3 | 0 | −100.0 | ★ | ||
| Total | 16 | 3 | −81.25 | ★ | ||
|
| ||||||
| Full Responder* | Subject 3 | No. of body areas | 3 | 1 | −66.67 | ★ |
| Motor tics/min | 1 | 1 | 0.00 | ‡ | ||
| Phonic tics/min | 2 | 0 | −100.0 | ★ | ||
| Motor tic severity | 4 | 1 | −75.00 | ★ | ||
| Phonic tic severity | 4 | 0 | −100.0 | ★ | ||
| Total | 14 | 3 | −78.58 | ★ | ||
|
| ||||||
| Non-Responder‡ | Subject 2 | No. of body areas | 4 | 4 | 0.00 | ‡ |
| Motor tics/min | 4 | 1 | −75.00 | ★ | ||
| Phonic tics/min | 3 | 2 | −33.34 | † | ||
| Motor tic severity | 4 | 4 | 0.00 | ‡ | ||
| Phonic tic severity | 4 | 4 | 0.00 | ‡ | ||
| Total | 19 | 15 | −21.06 | ‡ | ||
| 18 Month | ||||||
|
| ||||||
| Non-Responder‡ | Subject 1 | No. of body areas | 4 | 4 | 0.00 | ‡ |
| Motor tics/min | 2 | 2 | 0.00 | ‡ | ||
| Phonic tics/min | 2 | 1 | −50.00 | ★ | ||
| Motor tic severity | 4 | 4 | 0.00 | ‡ | ||
| Phonic tic severity | 4 | 2 | −50.00 | ★ | ||
| Total | 16 | 13 | −18.75 | ‡ | ||
|
| ||||||
| Mean Responder Outcomes
|
No. of body areas | 3.67 | 1.67 | −55.56 | ★ | |
| Motor tics/min | 2.34 | 1 | −41.67 | ★ | ||
| Phonic tics/min | 2.34 | 0.67 | −83.34 | ★ | ||
| Motor tic severity | 4 | 1.34 | −66.67 | ★ | ||
| Phonic tic severity | 3.67 | 0.67 | −83.34 | ★ | ||
| Total | 16 | 5.34 | −68.10 | ★ | ||
★
Full Responder: ≥40% improvement in MRTRS total score
†
Partial Responder=40%–25% improvement in MRTRS total score
‡
Non-Responder: < 25%improvement in MRTRS total score