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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Acta Biomater. 2016 May 31;41:273–281. doi: 10.1016/j.actbio.2016.05.038

Figure 5. NF-κB decoy ODN treatment reduced osteoclast activation, and has no significant effects on osteoblastic activity in the distal femur in response to UHMWPE particles with or without LPS.

Figure 5

(a) TRAP staining was used to determine active osteoclast number (upper panel), and alkaline phosphatase (ALP) was used to determine osteoblast number (lower panel). The TRAP+ (b) and ALP+ (c) cell numbers were counted manually, and the numbers were normalized as described in Materials and Methods section. PE: UHMWPE particles; UNT: untreated control; S-ODN: scrambled ODN. *p< .05, ** p< .01