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A) Cumulative release of Cyt c from FA-PEG-PLGA-coated NPs after exposure to various conditions of GHS. B) The capability of Cyt c-based NPs coated with FA-PEG-PLGA-SH to activate caspase-9 and -3, after exposure to the reducing agent glutathione (GHS). This capability is contrasted with native Cyt c and FA-PEG-PLGA-S-S-LA NP (LA= α-lactalbumin). C) Scheme of Cyt c release in the intracellular reducing environment to induce apoptosis.
