Table 1.
Differences in demographic and clinical characteristics among the cohorts at enrollment (n=368)
| Characteristic | Controls n=106 (28.8%) | AI therapy alone n=158 (42.9%) | Chemotherapy followed by AI therapy n=104 (28.3%) | Statistic | p-value |
|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Mean (SD) | |||
| Age (years) | 58.7 (5.91) | 61.7 (6.42) | 59.4 (5.49) | F(2,365)=9.1 | <0.001 |
| Education (years) | 14.7 (2.86) | 14.9 (2.85) | 14.8 (2.79) | KW=0.3 | 0.851 |
| NART-R score | 112.6 (9.14) | 108.7 (8.49) | 107.6 (8.66) | F(2,365)=9.7 | <0.001 |
| Weeks since diagnosis | 9.7 (4.15) | 9.6 (3.81) | t=0.3 | 0.788 | |
| Weeks since first surgery | 5.2 (3.00) | 5.2 (2.72) | t=0.1 | 0.901 | |
| Percent (n) | Percent (n) | Percent (n) | |||
| Married or partnered (yes) | 59.4 (63) | 63.3 (100) | 66.3 (69) | χ2=1.1 | 0.582 |
| White (yes) | 90.6 (96) | 97.5 (154) | 94.2 (98) | χ2=5.9 | 0.052 |
| Natural menopause (yes) | 84.9 (90) | 82.3 (130) | 80.8 (84) | χ2=1.3 | 0.535 |
| HRT-ever (yes) | 46.2 (49) | 52.5 (83) | 50.0 (52) | χ2=1.1 | 0.572 |
| Mastectomy (versus BCS) | 11.4 (18) | 20.2 (21) | FE | 0.048 | |
| Radiation therapy (yes) | 71.5 (113) | 69.2 (72) | FE | 0.348 | |
| Receipt of a taxane (yes) | 70.2 (73) | ||||
| Stage of disease: | |||||
| I | 86.1 (136) | 40.4 (42) | FE | <0.001 | |
| IIa | 11.4 (18) | 35.6 (37) | |||
| IIb | 2.5 (4) | 13.5 (14) | |||
| IIIa | 0.0 (0) | 10.6 (11) |
AI, aromatase inhibitor; SD, standard deviation; KW, Kruskal-Wallis Test; NART-R, North American Adult Reading Test (estimated verbal intelligence); HRT, hormone replacement therapy; BCS, breast conserving surgery; FE, Fisher’s Exact test.