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. 1991 Mar;44(3):208–210. doi: 10.1136/jcp.44.3.208

Ki-67 staining in histological subtypes of breast carcinoma and fine needle aspiration smears.

V Kuenen-Boumeester 1, T H Van Der Kwast 1, H A Van Laarhoven 1, S C Henzen-Logmans 1
PMCID: PMC496938  PMID: 1849518

Abstract

Thirty four cases of invasive breast carcinoma were analysed for heterogeneity of Ki-67 reactivity in a tumour, and proliferative activity in various histological subtypes was compared. The growth factions determined in areas of central and peripheral tumour were the same. Mucinous and lobular carcinoma showed lower Ki-67 activity than ductal carcinomas. When ductal carcinomas were subdivided according to their dominant growth pattern, the carcinomas with a solid or comedo growth pattern showed the highest proliferative activity. These results largely confirm data from previous cell kinetic studies on the incorporation of radioactively labelled thymidine. A correlation between the growth fraction determined by Ki-67 in fine needle aspiration smears and cryostat sections of corresponding tumours was shown, implying that the immunostaining of cytological smears gives a reliable impression of the growth fraction of a tumour and may therefore be used in prospective studies.

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Selected References

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