Figure 5.

SRT1720 improved cell functions of H₂O₂-induced senescent HUVECs. HUVECs were pre-treated with 0, 5, 10, 15, 20 μM SRT1720 respectively for 24 hours, followed by 300 μM H₂O₂ for 4 hours. A: Representative images and quantitative analysis of tube formation in HUVECs (×100 magnification). B: Migrated cells were stained and quantitative analysis was represented as fold of control. Values are mean ± SEM; n = 4, N.S. means no significant difference, *means P<0.05, **means P<0.01, vs. control. Scale bar indicated 100 μm. One-way ANOVA (Bonferroni post hoc test) was used.