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. 2016 Jul 15;8(7):2912–2925.

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Transcription factor Gax attenuated neointimal formation in the mouse carotid artery injury model. A. Adenovirus-mediated overexpression of Gax (Ad-Gax) markedly decreased neointimal formation in vivo. Representative hematoxylin and eosin stained carotid artery slices form of mouse treated with Ad-Gax or Ad-EGFP at fourteen days after carotid artery injury. B. The effect of Gax overexpression on neointima, media, and lumen in mouse carotid arteries at fourteen days after injury. C. The effect of Ad-Gax on neointimal lesion formation in mouse model of carotid artery injury as quantitated by intima/media ratio. *P<0.05 versus Ad-EGFP. D. Representative western blot images of VSMCs differentiation markers in mouse carotid arteries treated with Ad-Gax or Ad-EGFP at fourteen days after injury. E. Representative Western blot images of Rap1A in mouse carotid arteries at fourteen days after injury, and quantification of Rap1A protein expression showed that Rap1A level was downregulated in Ad-Gax-treated vascular compared with Ad-EGFP-treated vascular. *P<0.05 versus Ad-EGFP.