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. 2016 Jul 15;8(7):2926–2936.

Figure 7.

Figure 7

The correlation between circulating Tfh exhaustion and intrahepatic/intratumoral PD-L1 expression. Single cell preparations were obtained from the liver biopsies of HepB patients, or from the peritumor and tumor samples of HCC patients who had undergone resection. PD-L1 expression was examined by flow cytometry. (A) The MFI of PD-L1 in HepB patients’ liver cells and in HCC patients’ peritumor cells. (B) The MFI of PD-L1 in HCC patients’ tumor cells. Mean ± SD. One-way ANOVA and Tukey’s test. (C) The correlation between the IL-10 and IL-21 secretion by circulating Tfh cells after SEB stimulation, and the PD-L1 expression level in HCC tumor. P represent the Pearson correlation coefficient. (D) The frequency of CXCR5+ cells in CD4+ T cells and (E) the total number of CD4+CXCR5+ T cells in HepB liver biopsies or HCC tumor tissues.