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LDN-57444 inhibited the mechanical allodynia in the ipsilateral limbs following inoculation. LDN-57444 or DMSO was injected (i.t.) three consecutive days after inoculation (days 14-16) (mean ± SEM., n = 8). *P < 0.05, **P < 0.01, versus day 0. #P < 0.05 or ##P < 0.01, versus CIBP+DMSO (between the CIBP+DMSO rats and the CIBP+LDN-57444 rats). CIBP: Cancer-induced bone pain group.
