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The UCHL1 inhibitor attenuated the microglia or astrocytes activation in the L4-5 segments after TCI (A: Iba-1, B: GFAP). (a) Sham group; (b) Sham+DMSO group; (c) Sham+LDN-57444 4 µg group; (d) CIBP group; (e) CIBP+DMSO group; (f) CIBP+LDN-57444 4 µg group. **P < 0.01 vs. the sham group; ##P < 0.01 vs. the CIBP+DMSO group. Scale bar = 100 μm. (mean ± SEM., n = 6). CIBP: Cancer-induced bone pain group.
