Table 4.
Strong positive staining (2+/3+) of IL-17 correlates with moderate/poor differentiation and lymph node metastasis among analyzed clinicopathological characteristics of breast cancer
| Characteristics of breast cancer | n | Negative | Positive Combinations | |||
|---|---|---|---|---|---|---|
|
|
|
|||||
| 0 | 1+ | 2+/3+ | ||||
|
|
|
|
||||
| n (%) | n (%) | P | n (%) | P | ||
| Differentiation | ||||||
| Well+DCIS | 62 | 1 (1.6) | 28 (45.2) | 0.103 | 33 (53.2) | 0.048 |
| Moderately | 227 | 7 (3.0) | 69 (30.4) | 151 (66.5) | ||
| Poorly | 90 | 8 (8.9) | 33 (36.7) | 49 (54.4) | ||
| Tumor size | ||||||
| > 2 cm | 266 | 8 (3.0) | 95 (35.7) | 0.056 | 163 (61.3) | 0.096 |
| ≤ 2 cm | 113 | 8 (7.1) | 35 (31.0) | 70 (61.9) | ||
| Lymph node metastasis | ||||||
| Yes | 167 | 2 (1.2) | 52 (31.1) | 0.052 | 113 (67.7) | 0.008 |
| No | 212 | 14 (6.6) | 78 (36.8) | 120 (56.6) | ||
| Estrogen receptor | ||||||
| Positive | 283 | 10 (3.5) | 93 (32.9) | 0.454 | 180 (63.6) | 0.179 |
| Negative | 96 | 6 (6.3) | 37 (38.5) | 53 (55.2) | ||
| Progesterone receptor | ||||||
| Positive | 272 | 13 (4.8) | 99 (36.4) | 0.764 | 160 (58.8) | 0.404 |
| Negative | 107 | 3(2.8) | 31 (29.0) | 73 (68.2) | ||
| Her-2 | ||||||
| Positive | 331 | 13 (3.9) | 114 (34.4) | 0.440 | 204 (61.6) | 0.441 |
| Negative | 48 | 3 (6.3) | 16 (33.3) | 29 (60.4) | ||
| Clinical stage | ||||||
| 0+I+II | 312 | 12 (3.8) | 106 (34.0) | 0.510 | 194 (62.2) | 0.490 |
| III+IV | 67 | 4 (6.0) | 24 (35.8) | 39 (58.2) | ||
| Total | 379 | 16 | 130 | 233 | ||
Note: Her-2, human epidermal growth factor receptor 2. Positive combinations were compared with negatives (1+ or 2+/3+ vs. 0) for each category, respectively, using chi-square method.