Table 2.

Relationship between serum miRNA expression and clinical features

Clinical index		N	miR-21		χ2	P	miR-375		χ2	P
			High	Low			High	Low
Age (year)	≤60	68	33	35	0.128	0.721	39	29	3.195	0.074
	>60	58	30	28			24	34
Sex	Male	56	27	29	0.128	0.719	24	32	2.057	0.152
	Feamle	70	36	34			39	31
Tumor size (cm)	≤5	46	20	26	1.233	0.267	22	24	0.137	0.711
	>5	80	43	37			41	39
Infiltration depth	T1~T2	55	19	36	9.325	0.002	25	30	0.807	0.369
	T3~T4	71	44	27			28	33
Differentiation grade	Good	36	20	16	3.311	0.191	19	17	0.178	0.915
	Moderate	60	25	35			29	31
	Poor	30	18	12			15	15
TNM stage	Stage I	11	6	5	2.927	0.403	8	3	13.649	0.003
	Stage II	51	24	27			33	18
	Stage III	34	19	16			10	24
	Stage IV	30	20	10			12	18
Vascular invasion	Yes	46	36	10	23.146	<0.001	16	30	6.711	0.009
	No	80	27	53			47	33
Lymph node metastasis	Yes	50	36	20	8.229	0.004	17	33	8.488	0.004
	No	76	27	43			46	30
Radio-therapy sensitivity	Complete remission	26	7	19	11.539	0.003	10	16	1.762	0.414
	Partial remission	76	38	38			40	36
	Inefficacy	24	18	6			13	11
Recurrence	Yes	36	30	6	22.400	<0.001	16	20	0.622	0.430
	No	90	33	57			47	43