FIGURE 1.

Enrichment of non-B DNA structure at human mutation hotspots. (A) Co-localization of H-DNA- and Z-DNA-forming sequences with mutation hotspots in the human c-MYC promoter. Search results for H-DNA- or Z-DNA-forming sequences in the promoter region of the human c-MYC gene are shown. P0, P1 and P2, Exon 1, and Intron 1 of the human c-MYC gene are shown in the center. Potential H-DNA-forming sequences are shown on the left and potential Z-DNA-forming sequences are shown on the right. Chromosome breakpoints involved in c-MYC translocations in previous reports, or single-strand-specific S1 nuclease sensitive sites in cultured human cells are marked as red stars. (B) Co-localization of H-DNA-forming sequences within the human BCL-2 major breakpoint region. Search results for H-DNA-forming sequences in the upstream 70-bp from major breakpoint region of the human BCL-2 gene are shown on the left. Chromosome breakpoints involved in BCL-2 translocations in previous reports are marked as red stars on the right.