Table 1.

An H-DNA-forming sequence induces DNA instability in WT and deficient yeast.

^∗Number of yeast colonies with loss of Ura3 in 100,000 cells. At least 30,000 colonies were screened in each fragility assay.

^∗∗H/C represents the fold increase in genetic instability induced by H-DNA over control in the various yeast strains. H-DNA-induced significantly more mutants in all WT and deficient yeast strains. P-values < 0.05 in two-sided t-test comparing H-DNA vs. Control, from >3 repeats. H-DNA-induced mutation above control in all deficient yeast strains list above are significantly different from that from WT cells. P-values < 0.05 in Fisher’s exact test from >3 repeats.