Table 1.
Genotypic and allelic frequencies of MTHFR gene polymorphisms in childhood ALL and control subjects
| Polymorphisms |
ALL
n (%) |
Control
n (%) |
OR (95%CI) | p-value |
|---|---|---|---|---|
| rs1801131 (A1298C) | ||||
| AA | 21 (21.0) | 18 (15.0) | 1.00 | - |
| AC | 42 (42.0) | 83 (69.2) | 0.43 (0.21-0.90) | 0.037 |
| CC | 37 (37.0) | 19 (15.8) | 1.67 (0.72-3.86) | 0.283 |
| AC + CC | 63 (63.0) | 101 (84.2) | 0.53 (0.26-1.08) | 0.103 |
| Allele | ||||
| A | 84 (42.0) | 119 (49.6) | 1.00 | - |
| C | 116 (58.0) | 121 (50.4) | 1.36 (0.93-1.98) | 0.12 |
| rs1801133 (C677T) | ||||
| CC | 64 (64.0) | 92 (76.7) | 1.00 | - |
| CT | 36 (36.0) | 27 (22.5) | 1.25 (0.69-2.23) | 0.552 |
| TT | 0 (0.00) | 1 (0.8) | - | - |
| Allele | ||||
| C | 164 (82.0) | 211 (87.9) | - | - |
| T | 36 (18.0) | 29 (12.1) | 1.59 (0.94-2.71) | 0.105 |
| rs13306561 T>C | ||||
| TT | 87 (87.0) | 84 (70.0) | 1.00 | - |
| TC | 11 (11.0) | 33 (27.5) | 0.32 (0.15-0.68) | 0.002 |
| CC | 2 (2.0) | 3 (2.5) | 0.64 (0.11-3.95) | 0.680 |
| TC + CC | 13 (13.0) | 36 (30.0) | 0.35 (0.17-0.70) | 0.003 |
| Allele | ||||
| T | 185 (92.5) | 201 (83.7) | 1.00 | - |
| C | 15 (7.5) | 39 (16.3) | 0.42 (0.22-0.78) | 0.005 |