Table 4.
Association of MTHFR gene polymorphisms with demographic and clinical features of patients
| Factors | rs1801131 | p-value | rs1801133 | p-value | rs13306561 | p-value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AC | CC | CC | CT | TT | TT | TC | CC | ||||
| Sex | 0.437 | 0.435 | 0.337 | |||||||||
| Male | 10 | 24 | 24 | 38 | 20 | - | 51 | 5 | 2 | |||
| Female | 11 | 18 | 13 | 26 | 16 | - | 36 | 6 | 0 | |||
| Age at diagnosis (Year) | 6.4 ± 4.1 | 6.7 ± 3.9 | 5.6 ± 3.4 | 0.438 | 6.6 ± 3.6 | 5.5 ± 4.0 | - | 0.160 | 6.4 ± 3.9 | 4.7 ± 2.3 | 7.0 ± 4.2 | 0.337 |
| WBC (×106/mL) | 30.9 ± 36.8 | 25.9 ± 42.2 | 44.5 ± 63.4 | 0.268 | 34.3 ± 54.4 | 33.8 ± 44.5 | - | 0.962 | 32.4 ± 50.2 | 24.8 ± 22.2 | 149.5 ± 43.1 | 0.004 |
| Hemoglobin (g/dL) | 6.9 ± 2.1 | 7.1 ± 2.8 | 8.4 ± 2.0 | 0.033 | 7.9 ± 2.4 | 6.9 ± 2.4 | - | 0.062 | 7.5 ± 2.4 | 7.6 ± 2.5 | 8.9 ± 1.3 | 0.728 |
| Platelet (×106/mL) | 62.4 ± 56.7 | 55.2 ± 38.6 | 63.3 ± 54.5 | 0.757 | 65.3 ± 54.7 | 50.4 ± 34.9 | - | 0.157 | 59.2 ± 48.4 | 70.2 ± 55.5 | 38.5 ± 38.9 | 0.687 |
| Organomegally | 0.087 | 0.209 | 0.232 | |||||||||
| Positive | 17 | 29 | 34 | 50 | 30 | - | 68 | 10 | 2 | |||
| Negative | 3 | 11 | 3 | 13 | 4 | - | 17 | 0 | 0 | |||
| Lymph adenopathy | 0.684 | 0.463 | 0.290 | |||||||||
| Positive | 11 | 21 | 23 | 35 | 20 | - | 46 | 8 | 1 | |||
| Negative | 9 | 19 | 14 | 28 | 14 | - | 39 | 2 | 1 | |||
| Cerebrospinal fluid involvement | 0.418 | 0.118 | 0.004 | |||||||||
| Positive | 2 | 1 | 3 | 2 | 4 | - | 3 | 2 | 1 | |||
| Negative | 18 | 40 | 34 | 61 | 31 | - | 83 | 8 | 1 | |||