Figure 1. PSEN‐NTF‐subunit interacts with substrates during catalysis.

Lateral view of the membrane core of the γ‐secretase complex (PDB entry: 5FN3) with PSEN1‐NTF and ‐CTF coloured in orange and green, respectively, and catalytic Asp residues displayed as rod models. Additional subunits PSEN2, APH1 and NCT are shown in light green, pale brown and pale yellow, respectively. An arrow indicates the putative substrate entrance.