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. 2016 Jun 23;35(15):1707–1719. doi: 10.15252/embj.201694327

Figure 1. Function and structure of FRH.

Figure 1

  1. In the Neurospora crassa circadian core clock oscillator, FRH associates with FRQ and CK1a to form a repressor complex (FFC) that inhibits the positive‐acting white‐collar transcription factors (WC‐1 and WC‐2) which form the white‐collar complex (WCC). Stoichiometries of the components are not represented in the schematic. FFC composition has been estimated as 1 FRH molecule: 2 FRQ molecules (Cheng et al, 2005; Hurley et al, 2013), or 2 FRH molecules: 2 FRQ molecules (Lauinger et al, 2014).
  2. Structure of FRH from the large crystallographic cell with an accordingly colored domain map below.