Figure 2. Celiac disease specific motifs identified using IMUNE.

The vast majority of motifs that IMUNE identified as being CD sensitive and specific are versions of this eight amino acid motif (a). Numerous variations of the motif are highly enriched in many CD samples and have low enrichments in all HC samples (b) and every CD sample is significantly enriched in multiple versions of the motif. IMUNE also identified eight other motifs (c) that show notable differences in enrichments between many of the CD and HC samples.