Table 1. Summary table comparing the effects of IL-6 and LPS on trout spleen IgM⁺ B cells.

Immune function	IL-6	LPS
STAT3 transcription	Up-regulated	Up-regulated
SOCS3 transcription	Up-regulated	No effect
STAT3 phosphorylation	Activated	Activated
Mitogenic effects	Significant	Very significant
IgM secretion	Increased	Increased
mIgM expression	Increased	Increased
Total IgM expression	Increased	Increased
Blimp1 transcription	Up-regulated	No effect
ACKR2 transcription	Up-regulated	No effect
p65 translocation to nucleus	Yes	Yes
IL-1β transcription	No effect	Up-regulated
IL-8 transcription	No effect	Up-regulated
TNF-α transcription	No effect	Up-regulated
CATH1 transcription	No effect	Up-regulated
CATH2 transcription	Up-regulated	Up-regulated
Hepcidin transcription	No effect	No effect
BCR signaling to anti-IgM	Increased	Increased
MHC-II expression	Decreased	Increased
Phagocytic activity	No effect	Increased
CD80/86 transcription	No effect	Up-regulated
CD83 transcription	No effect	Up-regulated